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Health
Issues
According
to EPA:
Acute
Effects:
- Acute (short-term) exposure
to high levels of vinyl
chloride via inhalation in humans
has resulted in effects on the CNS,
such as dizziness, headaches, and
giddiness. (1,2,4)
- Vinyl chloride is reported to
be slightly irritating to the eyes
and respiratory tract in humans.
(1,2)
- Tests involving acute exposure
of animals, such as the LC50 test
in mice, have shown vinyl chloride
to have high acute toxicity from
inhalation exposure. (5)
Chronic
Effects (Noncancer):
- Liver
damage may result from chronic
(long-term) exposure to vinyl chloride
in humans, through both inhalation
and oral exposure. (1,2,4)
- Individuals occupationally exposed
to vinyl chloride through inhalation
have developed a set of symptoms
termed "vinyl
chloride disease," which
is characterized by liver damage,
effects on the lung, poor circulation
in the fingers, changes in the bones
at the end of the fingers, thickening
of the skin, and changes in the
blood. (1,2)
- Animal studies have reported
effects on the liver, kidney, and
CNS from chronic exposure to vinyl
chloride. (1,6,7)
- EPA has not established an RfC
or an RfD for vinyl chloride. (8)
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